• HLA D expressed by antigen presenting

  2018-10-30

  

  HLA-D, expressed by antigen presenting cells (APCs), hosts in the peptide-binding groove the antigenic fragments to present to T cell receptor (TCR) on cognate T cells. The polymorphisms of HLA-D molecules can change the amino-acid side chains of the binding pockets, altering the TCR-peptide-HLA-D i

• br Heart failure HF is a leading

  2018-10-30

  

  Heart failure (HF) is a leading cause of mortality worldwide and a major problem of global health causing around 5% of the acute hospital admissions and accounting for around 10% of hospitalized patients in Europe and the United States. Importantly, the number of patients with HF is steadily incre

• Traditional antimicrobial susceptibility tests include the d

  2018-10-30

  

  Traditional antimicrobial susceptibility tests include the disk diffusion test, E-test gradient diffusion test and broth dilution susceptibility tests. Although the tests are robust, they each rely on the growth of the bacteria to a dense culture while being exposed to the antibiotic panel. Conseque

• 4-ethylphenyl sulfate While we studied the prevalence of var

  2018-10-30

  

  While we studied the prevalence of variants in highly actionable genes, we did not include 4-ethylphenyl sulfate in which mutations could lead to conditions where no therapy exists to manage the consequences of the deleterious mutation (Berg et al., 2011) (e.g. Huntington disease, Prion disease or

• As to the significant differences PTPRG

  2018-10-30

  

  As to the significant differences, PTPRG missense coding variant carriers had significantly earlier onset of psychosis and each had a history of learning disabilities. PTPRG is a protein tyrosine phosphatase highly expressed in the hippocampus, striatum and neocortex and is highly upregulated during

• br Results br Conclusions The MR analysis

  2018-10-30

  

  Results Conclusions The MR analysis is a recent improvement in genetic epidemiology (Jansen et al., 2014; Ding et al., 2009; Didelez and Sheehan, 2007). The independent distribution of alleles/genotypes means that the association of a disease with a genetic variation would not be affected by c

• To summarize our work highlights the facts that ECs

  2018-10-29

  

  To summarize, our work highlights the facts that ECs maintain HIV-specific memory B cell responses associated to effective antiviral humoral activities and that Env-specific memory B cell responses are positively associated with the neutralization breadth in HLA-B*57+ ECs. We propose that promoting

• Far beyond the modest ambitions of

  2018-10-29

  

  Far beyond the modest ambitions of its inventors, MHB has contributed significantly to the practice of medicine, the guidance of public health policy, and the antibiotic drug discovery efforts of academic scientists and the biopharmaceutical industry. Based upon analysis of MIC profiles performed in

• br Data mining and bioinformatic analysis

  2018-10-29

  

  Data mining and bioinformatic analysis For proteomic inventory, a total of 256, 298 and 98 proteins were identified using nr NCBI database, IPI chicken database, and UniProtKb/Swiss-Prot database, respectively. For quantitative analysis, a total of 85 proteins were identified using the nr NCBI da

• br Funding sources The Lundbeck Foundation Denmark

  2018-10-29

  

  Funding sources The Lundbeck Foundation Denmark (R124-A11485 and R181-2014-3372) and Carlsberg Foundation Denmark (CF14-0561) are acknowledged for grants enabling the analysis (TBB grants). The overseas collaboration was supported by the Knud Hojgaard Foundation Denmark (j.nr. 45.462), the Oticon

• br Protein molecular evolution analysis The

  2018-10-29

  

  Protein molecular evolution analysis The protocol included new protein molecular evolution tests integrating patterns of nucleotide sequence similarities with protein tertiary structures. The MEGA program was used in calculations of codon usage statistics. Specifically, the ratios between observe

• br Acknowledgment br Data This paper presents tables and

  2018-10-29

  

  Acknowledgment Data This paper presents tables and charts describing the variation in how minutiae are marked on latent fingerprints by latent print examiners, in support of the article “Interexaminer variation of minutia markup on latent fingerprints” [1]. The underlying data was collected in

• br Acknowledgments br Data Table showed data on the

  2018-10-29

  

  Acknowledgments Data Table 1 showed data on the global gene expression profile in MCF-7 and MDA-MB-231 cell lines treated with vehicle (DMSO) or DS in vitro. Tables 2–4 showed gene ontology analysis based on molecular functions (Table 2), biological processes (Table 3), and cellular components

• On Fig there is typical

  2018-10-29

  

  On Fig. 3 there is typical PCR analysis of five plasmid-containing bacterial colonies. The scheme of the experiment was as follows. The DNA fragment of about 900bp was amplified by PCR and cloned in commercial pAL2-T vector (Evrogen). The universal oligonucleotide primers M13dir/M13rev and the worki

• br Experimental design materials and methods

  2018-10-29

  

  Experimental design, materials and methods We used the following steps to reconstruct data from Figs. 1B and 1C of Larkin et al. [2]. Fig. 1C of Larkin et al. [2] contains 3 lines representing the Kaplan-Meier estimates of survival probabilities for patients with negative programmed death 1 liga

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