• br Introduction The Ras superfamily of small GTPases

  2022-07-15

  

  Introduction The Ras superfamily of small GTPases is composed of more than 150 protein members involved in a wide variety of biological processes, such as proliferation, differentiation, cytoskeletal organization, and protein trafficking [1]. The Ras superfamily proteins act as molecular switches

• The opposite modulation observed for

  2022-07-15

  

  The opposite modulation observed for circulating LPI levels and WAT GPR55 az628 synthesis by nutritional status suggests that increased levels of LPI may down-regulate the expression of its receptor in WAT, whereas in conditions of low serum LPI levels, the expression of GPR55 is stimulated. Howeve

• br Gastrointestinal peptides and intestinal

  2022-07-15

  

  Gastrointestinal peptides and intestinal health Gastrointestinal peptides are intimately involved in the regulation of feeding behaviors, energy metabolism and bodyweight 36, 37, 38, 39, 40, 41. GPR120 has been demonstrated to induce secretion of two such peptides: GLP-1 and cholecystokinin (CCK)

• br Methods br Results br Discussion LPD in

  2022-07-15

  

  Methods Results Discussion LPD, in terms of insufficient secretion of progesterone by the CL, reflected by low serum progesterone levels can occur in IVF attempts using any kind of ovarian stimulation protocol (Fatemi et al., 2007, Garcia et al., 1981, Van der Linden et al., 2011). However,

• The following are the supplementary data related to this art

  2022-07-15

  

  The following are the supplementary data related to this article. Author contribution Conflict of interest Introduction Thrombosis (arterial and venous) is a major cause of vascular obstructive diseases including myocardial infarction, cerebral infarction and pulmonary embolism. Glycoprote

• br Acknowledgments This work was

  2022-07-15

  

  Acknowledgments This work was supported by the Russian Foundation for Basic Research [grant number 16-04-00205], The Russian Science Foundation [grant number 16-15-00235], Czech Academy of Sciences [grant number RVO 61388963], and the Technology Agency of the Czech Republic [grant number TE010200

• GlyRs are members of the

  2022-07-15

  

  GlyRs are members of the superfamily of Cys-loop receptors (CLRs) [3]. They form postsynaptic pentameric receptor complexes of α1 and β subunits anchored via the scaffolding protein gephyrin [4]. GlyRs are composed of several domains with the large N-terminal extracellular domain (ECD) important for

• The neuronal glycine receptor HSOR allopregnanolone pathway

  2022-07-15

  

  The neuronal glycine receptor/3α-HSOR/allopregnanolone pathway may also be extended to the central nervous effects of gelsemine and koumine in brain. 3α-HSOR is expressed in certain brain regions in rats and humans, such as the limbic system including hypothalamus, hippocampus and amygdala, in addit

• Fig demonstrates placental amino acid transporter protein co

  2022-07-14

  

  Fig. 7 demonstrates placental amino BIX 02565 sale transporter protein concentrations. While no change in the placental SNAT2 is effected in response to a high-fat diet in wt, a trend toward a reduction was seen in glut3 mice in response to a high-fat vs. chow diet (Fig. 7A and B). A high-fat diet

• br Conclusions We have shown

  2022-07-14

  

  Conclusions We have shown that despite the development of severe insulin intolerance and marked alterations in whole body substrate oxidation that Gcgr−/− mice are protected against olanzapine-induced hyperglycemia. Our data provides evidence that this protective effect is likely due in large par

• The observed CORT induced increase in Cx

  2022-07-14

  

  The observed CORT-induced increase in Cx43 phosphorylation at S368 may also contribute to GJIC disruption. Gap junction channel permeability is modulated through connexin phosphorylation (Moreno and Lau, 2007). Specifically, the phosphorylation of Cx43 on S368 has been previously shown to decrease i

• br Results br Discussion secretase mediated

  2022-07-14

  

  Results Discussion γ-secretase-mediated proteolysis of integral membrane proteins is required for diverse biological processes (Lal and Caplan, 2011). One γ-secretase target of particular interest is Notch, as recent work has shown Notch activity to be increased in obesity and associated metab

• In the thoracic spinal cord neither glacial acetic acid

  2022-07-14

  

  In the thoracic spinal cord, neither glacial acetic Cyprodime hydrochloride mg nor HBO2 had an effect on nNOS expression or expression of the phosphorylated β3 subunit of the GABAA receptor. This result was not unexpected due to the preponderance of nociceptive signaling in the lumbar versus thoraci

• citric acid Albumin is the major carrier of free fatty

  2022-07-14

  

  Albumin is the major carrier of free fatty acids (FFAs) in plasma [59], and harbours seven binding sites that are common to FFAs with a range of chain-lengths (C10-C18) across its three domains (Fig. 1a) [60,61]. In vitro, saturated, mono- and poly-unsaturated FFAs, with chain lengths ranging from C

• br Materials and methods br Results br Discussion

  2022-07-14

  

  Materials and methods Results Discussion Several studies highlighted an improvement of glycaemic control in diabetic patients receiving sunitinib, while the underlying mechanism remained still elusive [3], [4], [5], [6], [8]. The present study gives evidence that sunitinib directly and spec

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