• br Competing interests br Funding br Ethical approval

  2022-06-20

  

  Competing interests Funding Ethical approval Acknowledgement Introduction Hepatitis C is a disease that infects the liver through transmission of the hepatitis C virus (HCV). Because the symptoms of this infection are not pronounced, the infected individuals may not even be aware of t

• Glutathione transferases EC also referred to as glutathione

  2022-06-20

  

  Glutathione transferases (EC 2.5.1.18; also referred to as glutathione S-transferases, GSTs) are ubiquitous and promiscuous enzymes that catalyze various kinds of reactions involving a wide variety of substrates that are toxic and chemically reactive (Angelucci et al., 2005). The primary function of

• GPR belongs to the G

  2022-06-20

  

  GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty Matrine (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in bone marrow, s

• GPR shares a amino acid sequence identity in humans to

  2022-06-20

  

  GPR81 shares a 52% amino cotransport sequence identity in humans to GPR109A [1], [2], [3]. In addition, GPR81 is localized more specifically to the adipose tissue [3]. In 2008, lactate was discovered to be the endogenous ligand for GPR81 [9], [10]. Plasma lactate levels reach concentrations capable

• Conjugated BAs via S PR also activate

  2022-06-20

  

  Conjugated BAs via S1PR2 also activate ERK1/2- and AKT-signaling pathways leading to the growth and invasion of cholangiocarcinoma cells. The role of conjugated BAs via S1PR2 to regulate apoptosis or cancer progression remains to be dissected. Nevertheless, there is no doubt that the composition of

• The PCR based analysis of

  2022-06-20

  

  The PCR-based analysis of TRECs in general is laborious, technically challenging and comparison of results obtained in different laboratories is difficult as different normalization standards exist. Moreover the analysis is restricted to analysis of cell populations (Douek et al., 1998; Jamieson et

• antimalaria medication Restless running behavior was first d

  2022-06-20

  

  ‘Restless running behavior’ was first described in mice after administration of 30mg/kg i.p. ALX-5407 and was thought to be due to an augmentation of NMDA-induced dopamine activity [27]. The motor impairments caused by ALX-5407 were confirmed by Perry et al. [10] and extended to another sarcosine-de

• Medroxyprogesterone After initial validation of the ability

  2022-06-20

  

  After initial validation of the ability of Ad5-Cre virus to express Cre recombinase protein in glial cells in vitro and in vivo, we employed this virus to induce site-specific deletion of our target GlyT1 in the thalamus, through injection of the cKO GlyT1 mice. This transgenic line was constructed

• br Material and methods br Results br

  2022-06-20

  

  Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new Nevirapine synthesis with different structures have been synthesized

• A number of experimental data declare a tight

  2022-06-20

  

  A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in XEN445 and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari and Shrivastava, 2

• br STAR Methods br Introduction Secretase is a

  2022-06-18

  

  STAR★Methods Introduction γ-Secretase is a membrane-embedded proteolytic complex belonging to a diverse family of intramembrane-cleaving proteases and is composed of four integral membrane proteins: presenilin (PS), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer

• Recently some researchers working in

  2022-06-18

  

  Recently, some researchers working in China Pharmaceutical University developed novel FFA1 agonists some of which were found to be efficacious in the management of type 2 diabetes and with low toxicity. For instance, Zheng et al. [48] in their in vivo study using experimental animals, reported that

• The activation of GPR FFA signaling triggers the PLC

  2022-06-18

  

  The activation of GPR40/FFA1 signaling triggers the PLC/PIP2 signaling pathway and results in Ca2+ release from the endoplasmic reticulum (ER). Increased Ca2+ levels may lead to activation of different protein kinases, such as Ca2+/calmodulin-dependent protein kinase type IV, Akt, extracellular sign

• Several transgenic and knockout congenic

  2022-06-18

  

  Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig

• At the heart of ferroptosis is a process of

  2022-06-18

  

  At the heart of ferroptosis is a process of lethal lipid peroxidation, which is the oxidative addition of molecular oxygen (O2) to lipids, such as polyunsaturated fatty acyl tails in phospholipids. The first descriptions of such enzymatic reactions were in 1955 by Peterson and colleagues [50] and Ro

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