• We sought to determine whether T cell derived iPSCs

  2018-10-20

  

  We sought to determine whether T cell-derived iPSCs (TiPSCs) could be used to analyze neurological diseases. Several issues regarding the utilization of TiPSCs in neurological studies remain unresolved. First, previous studies indicated that each iPSC clone retains an epigenetic memory relating to t

• Among the epigenetic aberrations of iPSCs

  2018-10-20

  

  Among the epigenetic aberrations of iPSCs, DNA methylation is of particular importance. Previous studies showed that unique de novo differentially methylated (DMR) or hydroxymethylated regions (hDMR) are present in iPSCs compared with hESCs (Lister et al., 2011; Wang et al., 2013). Furthermore, the

• Others have reported both B and T

  2018-10-20

  

  Others have reported both B and T cell effects after osteolineage cell deletion (Ding and Morrison, 2013) but the promoter used in some of those studies, Col1(2.3), extends through many cell stages of osteolineage progression. Here we define that these osteolineage cell states provide distinctive fu

• Impaired neural migration and defects in

  2018-10-20

  

  Impaired neural migration and defects in the (-)-JQ1 cytoskeleton are well-known factors contributing to malformations during the cortical development (Pang et al., 2008). Reduced expression of NSUN2 in human NES cells impaired migration toward the chemoattractant FGF2. FGF2 is widely used to maint

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