• br Introduction Soluble guanylyl cyclase GC maintains vascul

  2022-07-08

  

  Introduction Soluble guanylyl cyclase (GC-1) maintains vascular function through the NO/GC-1/cGMP pathway [1,2] by catalyzing the conversion of GTP into cGMP (Fig. 1). The GC-1 heme prosthetic group binds NO with picomolar affinity, resulting in a 100- to 200-fold increase in catalytic activity.

• hydralazine hydrochloride To further investigate the possibl

  2022-07-08

  

  To further investigate the possible interaction of L1 with β1-sGC, a protein-ligand docking experiment was performed. Calculations were carried out with the program GOLD (version 5.2) [18], [34] and performed with the chemPLP scoring function [19], [34]. The ten lowest energy solutions presented a r

• The NF B family of transcription factors is

  2022-07-08

  

  The NF-κB family of transcription factors is involved in acquisition of resistance to anticancer drugs as well as to apoptosis. NF-κB-mediated mdr1 gene upregulation is part of the anti-apoptotic protection mechanism of proximal tubule (PT) dl 473 against cadmium-induced oxidative stress and apopto

• A few of the islet

  2022-07-08

  

  A few of the islet-specific proteins identified in the present study have previously been described in various contexts of pancreatic islets, i.e. PTPRN, SCG5, SCGN, SNAP25 and SNED1, validating the search algorithm applied and supporting the notion that also the novel proteins identified are indeed

• Acknowledgments Financial support from the National Natural

  2022-07-08

  

  Acknowledgments Financial support from the National Natural Science Foundation of China (81730094, 81473262 and 81573299) is gratefully acknowledged. This project was also supported by the “111 Project” from the Ministry of Education of China, the State Administration of Foreign Expert Affairs of C

• Post translational ubiquitination has been shown to regulate

  2022-07-08

  

  Post-translational ubiquitination has been shown to regulate a wide range of cellular responses, such as the synaptic trafficking and turnover of neurotransmitter receptors (Rape, 2018). Ubiquitination is also engaged in the modification of protein-protein interaction and intracellular signaling tra

• Histamine functions as a key neurotransmitter in

  2022-07-08

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, HBTU is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pathway (Bor

• br Materials and methods br Results br Discussion

  2022-07-08

  

  Materials and methods Results Discussion Neurotransmitter uptake is one of the most important aspects of synaptic transmission, it fact, the existence of a specific uptake system is one of the requisites that any neuroactive substance has to cover to be considered a neurotransmitter. It has

• It has also been demonstrated

  2022-07-07

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor XCT790 associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of PS1 [50], [51]. T

• Although several new elements i e

  2022-07-07

  

  Although several new elements (i.e., microsomes and NADPH) were added in E. coli cultures in the current study, the concentration of LacZ gene inducer, IPTG, to stimulate for the maximum production of β-galactosidase enzyme at media pH of 7.0 was observed to be the same as in the previous study (Fig

• Based on the above considerations the galactosidase gene

  2022-07-07

  

  Based on the above considerations, the β-galactosidase gene from Exiguobacterium acetylicum MF03 (not previously reported) was cloned, expressed and purified with the aim of assessing the potential of this novel enzyme for catalyzing reactions of synthesis and hydrolysis of glycosides. Because of E.

• In addition to the robust intracellular calcium mobilisation

  2022-07-07

  

  In addition to the robust intracellular calcium mobilisation, DHA and TUG-891 also induced MMP-9 granules release and superoxide production, supporting a key role of calcium in bovine neutrophil defense responses (Burgos et al., 2011). Pisani et al. (Pisani et al., 2009) described a reduction of bas

• In the present studies we found that genistein did

  2022-07-07

  

  In the present studies, we found that genistein did not antagonize fMLF-induced Ca2+ mobilization in FPR1-HL60 quizartinib and human neutrophils. Thus, the previously reported inhibitory effect of genistein on fMLF-stimulated degranulation, aggregation, and reactive oxygen species (ROS) production i

• Another important question for future

  2022-07-07

  

  Another important question for future studies will be whether FAAH inhibitors work to normalize impairments in fear extinction that are known to be produced by environmental insults such as exposure to abused drugs and stress 97, 103. Indeed, several authors have posited utility of FAAH inhibitors f

• The NuB complex interacts with Asf

  2022-07-06

  

  The NuB4 complex interacts with Asf1p, which plays a central role in controlling the flux of histones to the various chromatin assembly pathways. This interaction is also evolutionarily conserved having been detected in yeast, chicken and human Zalcitabine [27], [61], [104], [105]. Asf1p appears to

15784 records 389/1053 page Previous Next First page 上5页 386387388389390 下5页 Last page