• The present findings demonstrate for the first time in immat

  2022-06-24

  

  The present findings demonstrate for the first time in immature rats that hippocampal infusion of ET-1 results in a rapid and long-lasting decrease in regional cerebral blood flow (rCBF) and oxygen saturation (pO2). These data are in accord with the results of studies and adult animals, which have s

• Recently results obtained by our group have

  2022-06-24

  

  Recently, results obtained by our group have demonstrated that hEECs are able to secrete NPY into the extracellular medium and that this peptide can induce an increase in the [Ca]i of these cells (Jacques et al., 2003b). In light of these results and those obtained in this study, we can speculate th

• Our findings demonstrated that the expression level of full

  2022-06-23

  

  Our findings demonstrated that the expression level of full-length α1 sGC protein was higher in the malignant and benign breast tumors than that of normal tissues. Similarly, an increase in the expression of α1 sGC subunit has been detected in glioma cell lines [34]. Higher expressions of sGCα1 and

• In contrast the sGC activator BAY relaxed

  2022-06-23

  

  In contrast, the sGC activator BAY 58-2667 relaxed the CC in a concentration-dependent manner (Figure 4B), a response that was significantly increased in the CC of sGCβ1ki/ki mice compared with WT mice. The finding that BAY 58-2667 also possessed a corporal relaxing effect in WT mice is suggestive b

• Furthermore a direct thiol protective role of

  2022-06-23

  

  Furthermore, a direct thiol protective role of S-nitrosylation has been reported in animals [66]. Here, formation of higher order irreversible oxidative modifications, such as sulfinic and sulfonic acids were prevented by S-nitrosylation. All these observations underline the important role of ROS in

• focal adhesion kinase Studies with GSNOR knockout mice repor

  2022-06-23

  

  Studies with GSNOR knockout mice reported decreased CD4+ focal adhesion kinase and increased CD19+ cells (B-cell) in the blood [31] as well as demyelination, neurodegeneration, and neuropathic pain [29]. To understand the basis of these differences in immune function of GSNOR knockout mice and GSNO

• br GSK Glycogen synthase kinase GSK is a ubiquitous serine

  2022-06-23

  

  GSK-3 Glycogen synthase kinase-3 (GSK-3) is a ubiquitous serine/threonine kinase that is involved in multiple signaling pathways that are crucial for cellular metabolism and proliferation (Doble and Woodgett, 2003, Frame and Cohen, 2001, Grimes and Jope, 2001, Woodgett, 1990). GSK-3 is known to d

• br Material and methods br

  2022-06-23

  

  Material and methods Results Discussion The inhibitory action of a GABA agonist, muscimol, on the level of mRNA encoding GnRH in the POA-hypothalamus [25] of follicular-phase sheep has suggested that at the hypothalamic level GABA may exert a suppressive effect on subsequent steps of the Gn

• br Introduction L Glutamate is one

  2022-06-23

  

  Introduction L-Glutamate is one of the most prevalent excitatory signaling molecules in the central nervous system (CNS) (Salazar et al., 2016) and plays a crucial role in a variety of Orlistat functions such as memory and learning (Danbolt, 2001, Nedergaard et al., 2002). At elevated concentrat

• That MSCs release IL upon LPS stimulation

  2022-06-23

  

  That MSCs release IL-6 upon LPS stimulation or other stressful stimuli like H2O2 [43] is well-documented [44]. However, there are conflicting reports on the potential effects of this cytokine in stroke. Some studies have found that the external administration of IL-6 in ischemic animal models leads

• A number of anti diabetic drugs

  2022-06-23

  

  A number of anti-diabetic drugs are available that inhibit α-glucosidase activity, including acarbose, voglibose and miglitol [6,7]. These inhibitors, however, also exhibit undesirable side effects, such as adverse gastrointestinal symptoms and liver toxicity [8,9]. For diabetics, it would therefore

• It was previously proposed that glucagon acts in

  2022-06-23

  

  It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the ONC201 synthesis via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in the

• During the course of our optimization of the diarylsulfonami

  2022-06-22

  

  During the course of our optimization of the diarylsulfonamide chemotype as FFA4 agonists, we identified xanthene as a potent and selective antagonist of FFA4 (). Xanthene was able to block the agonist induced intracellular Ca response elicited by both linoleic sodium butyrate synthesis and compo

• According to the World Health

  2022-06-22

  

  According to the World Health Organization, the average global intake of fat has increased by 20 g per person over the last half-century [21]. However, not all fats are the same and it is now well established that saturated and unsaturated fats, as well as trans fats, can act in opposing ways to inf

• In addition to indoles two additional structural variants we

  2022-06-22

  

  In addition to indoles –, two additional structural variants were synthesized to explore the synthetic flexibility and structure–activity relationships of this system. The first of these was the homologation of the acetic GSK2636771 side chain to prepare compound (). The extension of the chain was

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