• Gastrointestinal tone can be effectively modulated by

  2020-08-12

  

  Gastrointestinal tone can be effectively modulated by cholinesterase inhibitors. As parasympathetic fibers release Pyr3 synthesis to contract the circular and longitudinal intestinal muscles, AChE inhibition can facilitate those actions. Postoperative ileus (delayed gastric emptying after surgery)

• As plants can only take

  2020-08-12

  

  As plants can only take up P in an inorganic orthophosphate form, it was expected that the proportion of orthophosphate P in the OA would be a good indication of the availability of the P in the OA. While the P speciation of the COMP sample could not be determined by deconvolution due to the broadne

• br Acknowledgements This study is sponsored by the Natural S

  2020-08-12

  

  Acknowledgements This study is sponsored by the Natural Science Foundation of China (grant no. 51178161), 111 Project (grant no. B13024) and the Fundamental Research Funds for the Central Universities (grant no. 2017B00914) Introduction Highway and pavement engineers are facing concrete pavem

• Binding affinity was measured by

  2020-08-12

  

  Binding affinity was measured by a scintillation proximity binding assay using [H]4-OHT (ERRγ) or [H]estradiol (ERα/β) as radioligand. In all cases, the ERβ affinity was not significantly different from ERα. Compounds were compared to , which showed high affinity for both receptors and moderate (six

• Grapiprant is a selective antagonist for prostaglandin

  2020-08-12

  

  Grapiprant () is a selective antagonist for prostaglandin E (PGE) receptor subtype 4 (EP4) identified as a clinical candidate for the treatment of inflammatory pain associated with osteoarthritis (OA). It is currently under development for use in humans and dogs. The projected dosing regimen of grap

• br Results br Discussion In this study we investigated the

  2020-08-12

  

  Results Discussion In this study, we investigated the role of EP4 on invasion and invadopodia in breast cancer cells. Our results demonstrate that EP4 activation promotes invadopodia-driven ECM degradation, in turn facilitating future intravasation and metastasis of breast cancer ll-37 (Gligo

• On the opposite side sPLA X has also been

  2020-08-12

  

  On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer TUG 891 and promotes their survival during nutrient stress. It acts through the products of its enzymatic

• Oral antipsychotics are substrates of CYP enzymes which are

  2020-08-11

  

  Oral antipsychotics are substrates of CYP450 enzymes, which are crucial to their metabolism and elimination (Fig. 1). The efficacy and toxicity of antipsychotic agents is affected by factors that induce or inhibit CYP450 expression and function, such as drug–drug interactions. Additionally, the mult

• With a favorable spectrum of CRTh dependent in

  2020-08-11

  

  With a favorable spectrum of CRTh2 dependent in vitro and in vivo efficacy demonstrated, the off-target activity of compound 18 was investigated, first against a panel of prostanoid receptors and related eicosanoid targets (Table 8), where no significant activities at 10μM concentration were found i

• br Proposed methodology At the outset

  2020-08-11

  

  Proposed methodology At the outset, the wind power outputs must be obtained which are to be included in the OPF model. This work utilizes a modified version of the simulation method. Rather than using the simulated wind power values for each hour of the year, the probability of each wind power in

• br Bipartite graph br Algorithm

  2020-08-11

  

  Bipartite graph Algorithm for CFC Error detection rate and overhead evaluation Test results and discussion For verifying the proof in alkylation of dna from the perspective of practice, this section brings tests and analysis based on the onboard computer (OBC) of the in-service ZDPS-1A

• br Acknowledgements This work was supported by a grant from

  2020-08-11

  

  Acknowledgements This work was supported by a grant from the Deutsche Forschungsgemeinschaft to Uwe Knippschild and Martin Wabitsch (SFB 1149/B4). P. Fischer-Posovszky is funded by a Margarete von Wrangell scholarship financed by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württem

• br Cholesterol handling in the

  2020-08-11

  

  Cholesterol handling in the arterial wall cells Foam cell formation in the arterial intima is a major hallmark of early-stage atherosclerotic lesions, which is attributed to uncontrolled uptake of modified lipoproteins, excess cholesterol esterification and impaired cholesterol release [44]. As a

• BCTC This study focused on NPC L because it

  2020-08-11

  

  This study focused on NPC1L1 because it is critical for intestinal BCTC of both dietary and biliary cholesterol.1, 7, 8 Overall, regulation in the intestine of cholesterol, BAs, and lipids by FGF19 and SHP may involve the combined actions of regulation of other genes that were identified in our int

• Previous studies showed that many steroidogenic

  2020-08-10

  

  Previous studies showed that many steroidogenic enzymes act when the enzyme binds to the cofactor first [30]. In the present study, we showed that HPTE inhibited both AKR1C14 and RDH2 in a mixed mode when cofactor was used. This indicates that HPTE interferes with cofactor-binding residues although

15784 records 781/1053 page Previous Next First page 上5页 781782783784785 下5页 Last page